Towards a Better Treatment of Parkinson's disease
نویسندگان
چکیده
....................................................................................................... 46 Abbreviations ............................................................................................... 46 Introduction .................................................................................................. 47 Materials and Methods ................................................................................. 50 Partial Lesion Model ............................................................................... 50 Cylinder Test .......................................................................................... 51 Results ......................................................................................................... 51 Model Verification ................................................................................... 51 Sensitivity of Cylinder Test.. ................................................................... 53 Consistency of Cylinder Test. ................................................................. 57 Correcting for Different Sets of Model Animals. ...................................... 59 Dose Response. ..................................................................................... 62 Therapeutic Effect of Raclopride. ........................................................... 66 Overall Therapeutic Effect of Raclopride ................................................ 68 Discussion .................................................................................................... 70 4. Discussion ......................................................................................................... 72 Discussion and Conclusion .......................................................................... 72 Introduction ............................................................................................ 72 Hypothesis ............................................................................................. 72 Electrophysiological Studies ................................................................... 72 Behavioral Studies ................................................................................. 73 Conclusion ............................................................................................. 74 References .................................................................................................................... 75
منابع مشابه
کاربرد سلول های بنیادی در درمان بیماری پارکینسون
Stem cells are undifferentiated cells with the ability to divide and differentiate into distinct cell types. The source of these cells is from embryos and adults, that each cell has its own specific characteristics. For nearly decades, experimental studies have been conducted to use these types of cells to treat various diseases. Parkinson's disease is one of the most common neurodegenerative d...
متن کاملOptimal design of a vibration absorber for tremor control of arm in Parkinson's disease
Because the underlying physiology of pathological tremor in a Parkinson's patient is not well understood, the existing physical and drug therapies have not been successful in tremor treatment. Different mathematical modeling of such vibration has been introduced to investigate the problem and reduce the existing vibration. Most of the models have represented the induced vibration as a sinusoida...
متن کاملThe Measurement of Rigidity in Elbow Joint: An Objective Method for the Evaluation of Parkinson's disease
Introduction: One of the most common syndromes in Parkinson's disease (PD) is rigidity. Currently, an index is used to evaluate the level of PD by the clinical measurement of rigidity in the upper extremity. The index uses a subjective method called Unified Parkinson's Disease Rating System (UPDRS). The subjective nature of this method makes the influence of physician in the measurement of rigi...
متن کاملEffects of Ferulago angulata Extract Against Oxidative Stress Induced by 6-hydroxydopamine in Rats
Background: Parkinson's disease is one of the prevalent degenerative diseases of the neural system. Oxidative stress, which has been recognized as the most important factor of Parkinson's disease, plays a main role in the death of neurons in this disease. Antioxidants have a proved role in the prevention of oxidative stress. Objective: Considering the presence of evidence regarding antioxid...
متن کاملThe antioxidant effect of hesperetin and nano-hesperetin on activity of catalase and superoxide dismutase enzymes in the hippocampus of animal model of Parkinson's disease
Background and objectives: Hesperetin flavanone is a natural bioflavonoid found abundantly in citrus fruits with antioxidant and anti-inflammatory properties. Nano sizing techniques improve the bioavailability of poorly soluble drugs such as hesperetin. Main feature of Parkinson's disease is the degeneration of dopaminergic neurons in the substantia nigra. The rate of oxidative...
متن کاملStrength-endurance training with olive oil consumption on motor performance and oxidative stress level in the brain of male parkinsonian rats.
Introduction: Parkinson's disease is a chronic brain disorder that occurs as a result of the loss, reduction or damage of dopamine-producing nerve cells in the substantia nigra located in the midbrain. The purpose of this study is to determine the effect of 8 weeks of strength-endurance training with olive oil consumption on motor performance and oxidative stress level in the brain of male park...
متن کامل